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You are a holobiont, I am a holobiont, we are all holobionts. "Holobiont" means, literally, "whole living creature." It ...

Showing posts with label Origin of life. Show all posts
Showing posts with label Origin of life. Show all posts

Wednesday, September 28, 2022

The Krebs Cycle: The Origin of Life?

 


You probably know Nick Lane for his books, such as the rather famous (among some slightly nerdy people, I read it twice!!) "The Vital Question." An older, but still interesting, book by Lane is "Oxygen, the Molecule that made the World."

Nick Lane was recently interviewed on "Nautilus" about his new book, "Transformer: the Deep Chemistry of Life." It is about the Krebs cycle, the engine that powers all the holobionts on this planet. Here, Lane describes how we may be finally cracking the mystery of the origins of life: an epochal discovery. You probably remember how, in the 1950s, it was discovered that the so-called "primordial soup" could generate aminoacids when exposed to ultraviolet rays or electrical discharges. Then, it became fashionable to think that life could have developed on Earth as the result of the assembling of aminoacids to form DNA or RNA molecules. It also became fashionable to think in terms of the "RNA world" that may have preceded the current molecular structure of cells.

Alas, it didn't work. Aminoacids stubbornly refused to assemble themselves into anything more than short-chain peptides, molecules akin to proteins, but much simpler and smaller. This field was gradually abandoned for lack of success in obtaining any useful results about the origin of life. . But now, Lane is reconsidering the idea with a new take: trying to see if it is possible to self-assemble the Krebs cycle or at least something that resembles the Krebs cycle. (Image from Wikipedia)


Fascinating story. I am going to order Lane's new book, even though I don't guarantee that I am nerdy enough to read it twice (maybe not even once), but I'll try.

And, as usual, onward, fellow holobionts!!